Dengue -sero type

Dengue fever, mainly found in the tropical and subtropical regions, is carried by mosquitoes. With the help of greenhouse effect, places considered to be a Dengue safe-zone are becoming more and more dangerous. Dengue fever shows similar aspects to MERS, which caused heavy casualties in South Korea; Dengue virus does not have clear treatments nor vaccines like MERS. Development of Dengue vaccine is actively investigated lately. However, it is not easy to succeed; the fact that Dengue’s 4 serotypes have different properties and that repeated infections worsen the symptoms. This research aims to analyze the 4 serotypes (DENV1, DENV2, DENV3, DENV4) using SVM and ANN algorithms to investigate the constraints in the development of Dengue’s vaccines and treatments.

 

 

플라비바이러스는 메르스와는 다른 형태의 바이러스입니다. 

우선 NCBI에서 뎅기 4종을 찾아서 검색합니다. 

 

폴리프로틴 type 1입니다. 

 

https://www.ncbi.nlm.nih.gov/protein/QIC53443.1

polyprotein [dengue virus type I] - Protein - NCBI

 

 

폴리프로틴 type 2입니다. 

 

https://www.ncbi.nlm.nih.gov/protein/NP_056776.2

polyprotein [Dengue virus type 2] - Protein - NCBI

 

폴리프로틴 type 3입니다. 

 

https://www.ncbi.nlm.nih.gov/protein/YP_001621843.1

polyprotein [Dengue virus type 3] - Protein - NCBI

 

폴리프로틴  type 4입니다.

https://www.ncbi.nlm.nih.gov/protein/NP_073286.1

polyprotein [Dengue virus type 4] - Protein - NCBI

 

폴리프로틴이라는것은 여러 개의 단백질이라는 의미입니다. 

뎅기의 구조를 보면 알 수 있는 것이 여러개의 subtype들로 구성되어 있습니다. 

 

https://www.ncbi.nlm.nih.gov/protein/?term=polyprotein+%5Bdengue+virus+type+4%5D 

polyprotein [dengue virus type 4] - Protein - NCBI

 

 

 

단백질에 대한 위키백과의 설명입니다.

 

https://ko.wikipedia.org/wiki/%EB%8B%A8%EB%B0%B1%EC%A7%88

단백질 - 위키백과, 우리 모두의 백과사전

 

 

뎅기 연구에 대한 관련 내용입니다. 

 

https://www.matec-conferences.org/articles/matecconf/abs/2016/32/matecconf_iccpe2016_01008/matecconf_iccpe2016_01008.html

Deeper understanding about the genetic structure of dengue virus using SVM | MATEC Web of Conferences