에볼라 바이러스 종류

A. Bundibugyo Ebolavirus (BDBV)

Bundibugyo ebolavirus, confirmed as Ebola in 2007, as new species of Ebola in 2008. It is one of four ebolavirus that causes EVD in humans. EVD due to BDBV infection cannot be differentiated from EVD caused by other Ebolaviruses by clinical observation alone. An epidemiological study determined there were 116 confirmed and probable cases of the new Ebola species, BDBV, and that the outbreak had a mortality rate of 34%(39 deaths) [3].

 

B. Reston Ebolavirus (RESTV)

Reston Ebolavirus was first described in 1990 as a new "strain" of Ebola virus, a result of mutation from Ebola virus. It is the single member of the species Reston ebolavirus, which is included into the genus Ebolavirus, family Filoviridae, order Mononegavirales. Despite its status as a level-4 organism, Reston virus is non-pathogenic to humans, though hazardous to monkeys; the perception of its lethality was confounded due to the monkey's coinfection with Simian hemorrhagic fever virus (SHFV).

 

C. Sudan Ebolavirus (SUDV)

Sudan Ebolavirus emerged in 1976; it was first assumed to be identical with the Zaire species. It is believed to have broken out first among factory workers. However the virus was not found in any of the local animals and insects that were tested in response. The carrier is still unknown.

 

D. TaiForest Ebolavirus (TAFV)

TaiForest Ebolavirus made its first and thus far only known appearance in 1994 during a viral hemorrhagic fever epizootic among western chimpanzees (Pan troglodytes verus) in Taï National Park, Côte d'Ivoire. As more dead western chimpanzees were discovered, many tested positive for infection with an ebolavirus distinct from those already known[4].

 

E. Zaire Ebolavirus (EBOV)

Electron micrographs of EBOV show them to have the characteristic threadlike structure of a filovirus. EBOV VP30 is around 288 amino acids long. The virions are tubular in general form but variable in overall shape and may appear as the classic shepherd's crook or eyebolt, as a U or a 6, or coiled, circular, or branched; laboratory techniques, such as centrifugation, may be the origin of some of these formations. The RNA genome of EBOV encodes at least 7 structural proteins. The ribonucleoprotein (RNP) complex that mediates transcription and replication of the viral genome comprises 4 of these proteins: nucleoprotein (NP), VP35, VP30, and the RNA-dependent RNA polymerase (L). The 3 other proteins—glycoprotein (GP), VP40, and VP24—are membrane-associated proteins [5].

 

 

 

[1] Ebola virus disease Fact sheet N°103, World Health Organization, March 2014, pp. 201-256.

[2] M. Eichner, S. F. Dowell, and N. Firese, "Incubation Period of Ebola Hemorrhagic Virus Subtype Zaire OH AND BRETT,” Osong Public Health and Research Perspectives, June 2011, vol. 2, no. 1, pp. 3-7.

[3] T. Hoenen, A. Groseth, D. Falzarano, and H. Feldmann "Ebola virus: unravelling pathogenesis to combat a deadly disease,” Trends in Molecular Medicine, 2006 May, vol.12, no. 5, pp. 206-215.

[4] J. W. King and A. A. Khan, "Medscape: Ebola virus, clinical presentation,” 2012.

[5] S. P. Fisher-Hoch et al., "Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola),” J. Infect. Dis, vol. 152, no. 5, pp. 887-894, November 1985.

 

 

 

출처: Analysis of Ebolavirus with Decision Tree and Apriori algorithm (International Journal of Machine Learning and Computing, Vol. 4, No. 6, December 2014.)